Unit Publications

Editorial Management

Each member of the Unit is involved in diverse research and non-research activities. Some are more devoted to teaching, others are editors, permanently or exceptionally during the time of a special issue. Here are some examples :

teaching

Dr. Pierre-Antoine DEFOSSEZ

Editor at ‘Nucleic Acids Research‘

 

 

teachingDr. Claire FRANCASTEL

Editor at ‘Scientific Reports‘

Guest Editor at ‘Biology‘ for a special issue : ‘DNA Modifications and Their Alterations in Disease‘
 

 

teaching

Dr. Florent HUBE
Editor at ‘Non-coding RNA (MDPI)
Editor at ‘J (MDPI)
Associate Editor at ‘Frontiers in genetics, section RNA
Guest Editor at ‘Non-coding RNA‘ for a topical collection : ‘Non Coding RNA Methods‘
Guest Editor at ‘Frontiers in BioScience‘ for a special issue : ‘Genetics and Epigenetics, who decides ?‘
Guest Editor at ‘Frontiers in Genetics & Frontiers in Molecular Biosciences, section RNA‘ for a special issue : ‘Intron-centric transcription and its role in normal physiology and disease‘

teaching

Dr. Claire ROUGEULLE

Editor at ‘Non-coding RNA‘
Guest Editor at ‘Non-coding RNA‘ for a special issue : ‘Long non-coding RNAs, from an Evolutionary Perspective‘

 

 

teaching

Dr. Guillaume VELASCO

Guest Editor at ‘Biology‘ for a special issue : ‘DNA Modifications and Their Alterations in Disease‘ 

 

 

Publications by Teams

Aït-Si-Ali – Epigenetics Dynamics & Cellular Differenciation
Cosson – Post Transcriptional & Epigenetic Regulation
Defossez – DNA Methylation Dynamic of Eukaryotic Genome
Francastel – DNA Methylation and Non -Coding Rna in Health and Disease
Mezger – Developement and Environment Interface
Polo – Epigenome Integrity
Rougeulle – Non-Coding Rnas, Differenciation and Development
Weitzman – Plasticity of Cellular Phenotypes

 

Unit Publications (update May 2018)

 

  • Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H. CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome. J Clin Invest. 2018; doi: 10.1172/JCI99751. PMID: 30307408
  • Toubiana S, Velasco G, Chityat A, Kaindl AM, Hershtig N, Tzur-Gilat A, Francastel C, Selig S. Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric Instability and Facial Anomalies (ICF) syndrome. Human Mol Genet. 2018; 27(20):3568-3581. PMID: 30010917
  • Velasco G, Grillo G, Touleimat N, Ferry L, Ivkovic I, Ribierre F, Deleuze JF, Chantalat S, Picard C, Francastel C. Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state. Human Mol Genet. 2018; 27(14):2409-2424. PMID: 29659838
  • Hubé F, Francastel C. Coding and non-coding RNAs, the frontier has never been so blurred. Front Genet. 2018; 9:140. PMID: 29720998
  • Tosolini M, Brochard V, Adenot P, Chebrout M, Grillo G, Navia V, Beaujean N, Francastel C, Bonnet-Garnier A, Jouneau A. Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells. Sci Rep. 2018; 8(1):5776. PMID: 29636490
  • Bogard B, Francastel C, Hubé F. A new method for the identification of thousands of circular RNAs . Non-coding RNA Investig. 2018; 2(5). Paper here
  • Furlan G, Gutierrez Hernandez N, Huret C, Galupa R, van Bemmel JG, Romito A, Heard E, Morey C, Rougeulle C. The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products.2018 May 3;70(3):462-472.e8. PMID: 29706539
  • Ouimette JF, Rougeulle C, Veitia RA. Three-dimensional genome architecture in health and disease.2018 Jan 29. PMID: 29377081
  • Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O , Amouroux R, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Okano M, Ait-si-ali S, Leonhardt H, Hajkova P, Marto J, Arita K, Shinkai Y, Defossez PA. A histone mimic within DNA Ligase 1 links DNA replication and DNA remethylation: a revised model for the maintenance of DNA methylation by UHRF1. Molecular Cell. 2017 67(4):550-565. PMID: 28803780
  • Naciri I, Roussel-Gervais A , Defossez PA, Kirsh O. Nouvelles fonctions d’une protéine liant l’ADN méthylé dans le cancer. Médecine/Sciences. 2017 33(8-9). PMID: Click Here
  • Naciri I, Defossez PA, Kirsh O. Encyclopædia Universalis 2016. La science au présent , 2017
  • Miozzo F, Arnould H, de Thonel A, Schang AL, Sabéran-Djoneidi D, Baudry A, Schneider B, Mezger V. Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms. Cell Stress Chaperones. 2017 Jul 15. PMID: 28712054
  • Schang AL, Sabéran-Djoneidi D, Mezger V. The impact of epigenomic Next Generation Sequencing approaches on our understanding of neuropsychiatric disorders. Clin Genet. 2017 Jul 11. PMID: 28696507
  • Achour C, Bogard B, Hubé F, Mani SA, Santulli G, Taube JH. The Non-Coding RNA Journal Club: Highlights on Recent Papers-5. Non-Coding RNA 2017, 3(2), 21. Paper here
  • Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nat Commun. 2017 May 2;8:15157. PMID: 28462912
  • Dabin J, Polo SE. Choreography of parental histones in damaged chromatin. Nucleus. 2017 May 4;8(3):255-260. PMID: 28448742
  • Fortuny A, Polo SE. Genome and Epigenome Maintenance by Keeping Histone Turnover in Check. Mol Cell. 2017 Apr 6;66(1):3-4. PMID: 28388440
  • Polo SE. Switching genes to silent mode near DNA double-strand breaks. EMBO Rep. 2017 May;18(5):659-660. PMID: 28336777
  • Gatto S, Gagliardi M, Franzese M, Leppert S, Papa M, Cammisa M, Grillo G, Velasco G, Francastel C, Toubiana S, D’Esposito M, Angelini C, Matarazzo MR. ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. Nucleic Acids Res. 2017 Jun 2;45(10):5739-5756. PMID: 28334849
  • Middleton R, Gao D, Thomas A, Singh B, Au A, Wong JJ, Bomane A, Cosson B, Eyras E, Rasko JE, Ritchie W. IRFinder: assessing the impact of intron retention on mammalian gene expression. Genome Biol. 2017 Mar 15;18(1):51. PMID: 28298237
  • Hédouin S, Grillo G, Ivkovic I, Velasco G, Francastel C. CENP-A chromatin disassembly in stressed and senescent murine cells. Sci Rep. 2017 Feb 10;7:42520. PMID: 28186195
  • Cheeseman KM, Weitzman JB. [What makes a parasite”transforming”? Insights into cancer from the agents of an exotic pathology, Theileria spp]. Bull Soc Pathol Exot. 2017 Feb;110(1):55-60. PMID: 28155040
  • Sagie S, Toubiana S, Hartono SR, Katzir H, Tzur-Gilat A, Havazelet S, Francastel C, Velasco G, Chédin F, Selig S. Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. Nat Commun. 2017 Jan 24;8:14015. PMID: 28117327
  • Tomaz RA, Harman JL, Karimlou D, Weavers L, Fritsch L, Bou-Kheir T, Bell E, Del Valle Torres I, Niakan KK, Fisher C, Joshi O, Stunnenberg HG, Curry E, Ait-Si-Ali S, Jørgensen HF, Azuara V. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Development. 2017 Feb 15;144(4):567-579. PMID: 28087629
  • Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. Cell Stem Cell. 2017 Jan 5;20(1):102-111. PMID: 27989768
  • Beyer S, Pontis J, Schirwis E, Battisti V, Rudolf A, Le Grand F, Ait-Si-Ali S. Erratum: Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation. Cell Discov. 2016 Nov 15;2:16043. PMID: 27867535
  • Beyer S, Robin P, Ait-Si-Ali S. Tandem Affinity Purification Approach Coupled to Mass Spectrometry to Identify Post-translational Modifications of Histones Associated with Chromatin-Binding Proteins. Methods Mol Biol. 2017;1507:13-21. PMID: 27832529
  • Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, De Thonel A, Svrcek M, Goloudina AR, Dumont S, Hammann A, Biard DS, Demidov ON, Seigneuric R, Duval A, Collura A, Jego G, Garrido C. HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene. 2017 Apr 20;36(16):2328-2336. PMID: 27819670
  • Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis. Cancer Res. 2017 Jan 1;77(1):62-73. PMID: 27815388
  • Beyer S, Pontis J, Schirwis E, Battisti V, Rudolf A, Le Grand F, Ait-Si-Ali S. Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation. Cell Discov. 2016 Oct 18;2:16037. PMID: 27790377
  • Richetto J, Massart R, Weber-Stadlbauer U, Szyf M, Riva MA, Meyer U. Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders. Biol Psychiatry. 2017 Feb 1;81(3):265-276. PMID: 27769567
  • Cheeseman K, Certad G, Weitzman JB. [Parasites and cancer: is there a causal link?]. Med Sci (Paris). 2016 Oct;32(10):867-873. PMID: 27758751
  • Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo SE. Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage. Mol Cell. 2016 Oct 6;64(1):65-78. PMID: 27642047
  • Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais JC, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. PMID: 27621446
  • Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L. E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. PMID: 27621431
  • Nikolaienko RM, Hammel M, Dubreuil V, Zalmai R, Hall DR, Mehzabeen N, Karuppan SJ, Harroch S, Stella SL, Bouyain S. Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J Biol Chem. 2016 Oct 7;291(41):21335-21349. PMID: 27539848
  • Cantone I, Bagci H, Dormann D, Dharmalingam G, Nesterova T, Brockdorff N, Rougeulle C, Vallot C, Heard E, Chaligne R, Merkenschlager M, Fisher AG. Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming. Nat Commun. 2016 Aug 10;7:12354. PMID: 27507283
  • Santolini M, Sakakibara I, Gauthier M, Ribas-Aulinas F, Takahashi H, Sawasaki T, Mouly V, Concordet JP, Defossez PA, Hakim V, Maire P. MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis. Nucleic Acids Res. 2016 Oct 14;44(18):8621-8640. PMID: 27302134
  • Boyarchuk E, Robin P, Fritsch L, Joliot V, Ait-Si-Ali S. Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry. J Vis Exp. 2016 May 17;(111).PMID: 27286495
  • Dabin J, Fortuny A, Polo SE. Epigenome Maintenance in Response to DNA Damage. Mol Cell. 2016 Jun 2;62(5):712-27. PMID: 27259203
  • Casanova M, Liyakat Ali TM, Rougeulle C. Enlightening the contribution of the dark matter to the X chromosome inactivation process in mammals. Semin Cell Dev Biol. 2016 Aug;56:48-57. PMID: 27174438
  • Furlan G, Rougeulle C. Function and evolution of the long noncoding RNA circuitry orchestrating X-chromosome inactivation in mammals. Wiley Interdiscip Rev RNA. 2016 Sep;7(5):702-22. PMID: 27173581
  • Kebir O, Chaumette B, Rivollier F, Miozzo F, Lemieux Perreault LP, Barhdadi A, Provost S, Plaze M, Bourgin J; ICAAR team, Gaillard R, Mezger V, Dubé MP, Krebs MO. Methylomic changes during conversion to psychosis. Mol Psychiatry. 2017 Apr;22(4):512-518. PMID: 27113994
  • Battisti V, Pontis J, Boyarchuk E, Fritsch L, Robin P, Ait-Si-Ali S, Joliot V. Unexpected Distinct Roles of the Related Histone H3 Lysine 9 Methyltransferases G9a and G9a-Like Protein in Myoblasts. J Mol Biol. 2016 Jun 5;428(11):2329-43. PMID: 27056598
  • Lakisic G, Lebreton A, Pourpre R, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P, Bierne H. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. PLoS Genet. 2016 Mar 3;12(3):e1005898. PMID: 26938916
  • Sterlin D, Velasco G, Moshous D, Touzot F, Mahlaoui N, Fischer A, Suarez F, Francastel C, Picard C. Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey. J Clin Immunol. 2016 Feb;36(2):149-59. PMID: 26851945
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PMID: 26799652
  • Nguyen LS, Lepleux M, Makhlouf M, Martin C, Fregeac J, Siquier-Pernet K, Philippe A, Feron F, Gepner B, Rougeulle C, Humeau Y, Colleaux L. Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology. Mol Autism. 2016 Jan 8;7:1. PMID: 26753090
  • Ouimette JF, Rougeulle C. How Many Non-coding RNAs Does It Take to Compensate Male/Female Genetic Imbalance? Adv Exp Med Biol. 2016;886:33-49. PMID: 26659486
  • Prudhomme J, Dubois A, Navarro P, Arnaud D, Avner P, Morey C. A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells. Epigenetics Chromatin. 2015 Dec 1;8:52. PMID: 26628922
  • Berindan-Neagoe I, Calin GA, Francastel C, Hubé F, Santulli G. The Non-Coding RNA Journal Club: Highlights on Recent Papers-3. Non-coding RNA. 2015 December, 1(3), 285-288. Paper here
  • Wright DG, Marchal C, Hoang K, Ankney JA, Nguyen ST, Rushing AW, Polakowski N, Miotto B, Lemasson I. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget. 2016 Jan 12;7(2):1687-706. PMID: 26625199
  • Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D. Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY). 2015 Nov;7(11):986-1003. PMID: 26583757
  • Prudhomme J, Morey C. Epigenesis and plasticity of mouse trophoblast stem cells. Cell Mol Life Sci. 2016 Feb;73(4):757-74. PMID: 26542801
  • Miozzo F, Sabéran-Djoneidi D, Mezger V. HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes. J Mol Biol. 2015 Dec 4;427(24):3793-816. PMID: 26482101
  • Polo SE, Almouzni G. Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model. DNA Repair (Amst). 2015 Dec;36:114-21. PMID: 26429064
  • Simon JM, Parker JS, Liu F, Rothbart SB, Ait-Si-Ali S, Strahl BD, Jin J, Davis IJ, Mosley AL, Pattenden SG. A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. J Biol Chem. 2015 Oct 23;290(43):26088-102. PMID: 26338712
  • Francastel C, Hubé F, Mani SA, Santulli G Taube JH, Szweykowska-Kulinska Z. The Non-Coding RNA Journal Club: Highlights on Recent Papers-2. Non-coding RNA. 2015 September, 1(2), 167-169. Paper here
  • Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat Commun. 2015 Jul 28;6:7870. PMID: 26216346
  • Mozzetta C, Boyarchuk E, Pontis J, Ait-Si-Ali S. Sound of silence: the properties and functions of repressive Lys methyltransferases. Nat Rev Mol Cell Biol. 2015 Aug;16(8):499-513. PMID: 26204160
  • Duval R, Fritsch L, Bui LC, Berthelet J, Guidez F, Mathieu C, Dupret JM, Chomienne C, Ait-Si-Ali S, Rodrigues-Lima F. An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides. Anal Biochem. 2015 Oct 1;486:35-7. PMID: 26099937
  • Cheeseman K, Weitzman JB. Host-parasite interactions: an intimate epigenetic relationship. Cell Microbiol. 2015 Aug;17(8):1121-32. PMID: 26096716
  • Suchyta M, Miotto B, McGarry TJ. An inactive geminin mutant that binds cdt1. Genes (Basel). 2015 May 15;6(2):252-66. PMID: 25988259
  • Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, Rougeulle C, Pain B, Bourillot PY, Savatier P. Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency. Nat Commun. 2015 May 13;6:7095. PMID: 25968054
  • Adam S, Dabin J, Polo SE. Chromatin plasticity in response to DNA damage: The shape of things to come. DNA Repair (Amst). 2015 Aug;32:120-126. PMID: 25957486
  • Giri S, Aggarwal V, Pontis J, Shen Z, Chakraborty A, Khan A, Mizzen C, Prasanth KV, Ait-Si-Ali S, Ha T, Prasanth SG. The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin. Elife. 2015 Apr 29;4. PMID: 25922909
  • Vallot C, Ouimette JF, Makhlouf M, Féraud O, Pontis J, Côme J, Martinat C, Bennaceur-Griscelli A, Lalande M, Rougeulle C. Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape. Cell Stem Cell. 2015 May 7;16(5):533-46. PMID: 25921272
  • Putois O, Villa F, Weitzman JB. Lost in post-translation. EMBO Rep. 2015 Jun;16(6):671. PMID: 25882226
  • Adam S, Dabin J, Bai SK, Polo SE. Imaging local deposition of newly synthesized histones in UVC-damaged chromatin. Methods Mol Biol. 2015;1288:337-47. PMID: 25827889
  • Hub&eacute F, Francastel C. Mammalian introns: when the junk generates molecular diversity. Int J Mol Sci. 2015 Feb 20;16(3):4429-52. PMID: 25710723
  • Gomez GA, McLachlan RW, Wu SK, Caldwell BJ, Moussa E, Verma S, Bastiani M, Priya R, Parton RG, Gaus K, Sap J, Yap AS. An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Mol Biol Cell. 2015 Apr 1;26(7):1249-62. PMID: 25631816
  • Ferracin M, Gautheret D, Hubé F, Mani SA, Ørom UA, Santulli G, Slotkin RK, Szweykowska-Kulinska Z, Taube JH, Vazquez F, Yang JH. The Non-Coding RNA Journal Club: Highlights on Recent Papers. Non-coding RNA. 2015 June 17;1(1):87-93. Paper here
  • Corbett Y, Häfner S. Crystal myth. Microbes Infect. 2015 Mar;17(3):169-72. PMID: 25631816
  • Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature. 2015 Apr 16;520(7547):378-82. PMID: 25624101
  • Lazorthes S, Vallot C, Briois S, Aguirrebengoa M, Thuret JY, St Laurent G, Rougeulle C, Kapranov P, Mann C, Trouche D, Nicolas E. A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus. Nat Commun. 2015 Jan 20;6:5971. PMID: 25601475
  • Yahiro K, Akazawa Y, Nakano M, Suzuki H, Hisatune J, Isomoto H, Sap J, Noda M, Moss J, Hirayama T. Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway. Cell Death Discov. 2015 Sep 28;1:15035. PMID: 27551466
  • Kropp J, Degerny C, Morozova N, Pontis J, Harel-Bellan A, Polesskaya A. miR-98 delays skeletal muscle differentiation by down-regulating E2F5. Biochem J. 2015 Feb 15;466(1):85-93. PMID: 25422988
  • Mozzetta C, Pontis J, Ait-Si-Ali S. Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2. Antioxid Redox Signal. 2015 Jun 1;22(16):1365-81. PMID: 25365549
  • Joliot V, Ait-Mohamed O, Battisti V, Pontis J, Philipot O, Robin P, Ito H, Ait-Si-Ali S. The SWI/SNF subunit/tumor suppressor BAF47/INI1 is essential in cell cycle arrest upon skeletal muscle terminal differentiation. PLoS One. 2014 Oct 1;9(10):e108858. PMID: 25271443
  • Dubreuil V, Sap J, Harroch S. Protein tyrosine phosphatase regulation of stem and progenitor cell biology. Semin Cell Dev Biol. 2015 Jan;37:82-9. PMID: 25256403
  • Ulveling D, Dinger ME, Francastel C, Hub&eacute F. Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs. Front Genet. 2014 Sep 9;5:316. PMID: 25250049
  • Villanueva SY. Reservoir rats. Interview by Sophia Häfner. Microbes Infect. 2014 Nov;16(11):877-80. PMID: 25240478
  • Makhlouf M, Ouimette JF, Oldfield A, Navarro P, Neuillet D, Rougeulle C. A prominent and conserved role for YY1 in Xist transcriptional activation. Nat Commun. 2014 Sep 11;5:4878. PMID: 25209548
  • Walton EL, Francastel C, Velasco G. Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases. Biology (Basel). 2014 Sep 5;3(3):578-605. PMID: 25198254
  • Marsolier J, Weitzman JB. [Pin1: a multi-talented peptidyl prolyl cis-trans isomerase and a promising therapeutic target for human cancers]. Med Sci (Paris). 2014 Aug-Sep;30(8-9):772-8. PMID: 25174754
  • David J, Häfner S. Flatland goes 3D. Microbes Infect. 2014 Sep;16(9):707-10. PMID: 25124543
  • Adam S, Polo SE. Blurring the line between the DNA damage response and transcription: the importance of chromatin dynamics. Exp Cell Res. 2014 Nov 15;329(1):148-53. PMID: 25062983
  • El Fatimy R, Miozzo F, Le Mouël A, Abane R, Schwendimann L, Sabéran-Djoneidi D, de Thonel A, Massaoudi I, Paslaru L, Hashimoto-Torii K, Christians E, Rakic P, Gressens P, Mezger V. Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome. EMBO Mol Med. 2014 Aug;6(8):1043-61. PMID: 25027850
  • Qibing L. Dear prudence. Interview by Sophia Häfner. Microbes Infect. 2014 Aug;16(8):587-90. PMID: 24973544
  • Papanayotou C, Benhaddou A, Camus A, Perea-Gomez A, Jouneau A, Mezger V, Langa F, Ott S, Sabéran-Djoneidi D, Collignon J. A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation. PLoS Biol. 2014 Jun 24;12(6):e1001890. PMID: 24960041
  • Polo SE. Reshaping chromatin after DNA damage: the choreography of histone proteins. J Mol Biol. 2015 Feb 13;427(3):626-36. PMID: 24887097
  • Häfner S. Freddy meets Wagner. Microbes Infect. 2014 Jun;16(6):451-3. PMID: 24819213
  • Velasco G, Walton EL, Sterlin D, Hédouin S, Nitta H, Ito Y, Fouyssac F, Mégarbané A, Sasaki H, Picard C, Francastel C. Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology. Orphanet J Rare Dis. 2014 Apr 17;9:56. PMID: 24742017
  • Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014 May 7;82(3):560-72. PMID: 24726381
  • Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman-Smook H, Pugh D, Debatisse M, He F, Zhang L, Defossez PA. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep. 2014 Apr 24;7(2):575-87. PMID: 24726359
  • Adam S, Polo SE, Almouzni G. How to restore chromatin structure and function in response to DNA damage–let the chaperones play: delivered on 9 July 2013 at the 38th FEBS Congress in St Petersburg, Russia. FEBS J. 2014 May;281(10):2315-23. PMID: 24673849
  • Truffi M, Dubreuil V, Liang X, Vacaresse N, Nigon F, Han SP, Yap AS, Gomez GA, Sap J. RPTPα controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin. J Cell Sci. 2014 Jun 1;127(Pt 11):2420-32. PMID: 24652832
  • Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness. Am J Pathol. 2014 May;184(5):1489-502. PMID: 24650563
  • Weitzman MD, Weitzman JB. What’s the damage? The impact of pathogens on pathways that maintain host genome integrity. Cell Host Microbe. 2014 Mar 12;15(3):283-94. PMID: 24629335
  • Jego G, Lanneau D, De Thonel A, Berthenet K, Hazoumé A, Droin N, Hamman A, Girodon F, Bellaye PS, Wettstein G, Jacquel A, Duplomb L, Le Mouël A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C. Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia. 2014 Aug;28(8):1676-86. PMID: 24504023
  • de Thonel A, Hazoumé A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C. Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. Cell Death Dis. 2014 Jan 23;5:e1016. PMID: 24457960
  • Mozzetta C, Pontis J, Fritsch L, Robin P, Portoso M, Proux C, Margueron R, Ait-Si-Ali S. The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell. 2014 Jan 23;53(2):277-89. PMID: 24389103
  • Defossez PA. Ceci n’est pas une DNMT: recently discovered functions of DNMT2 and their relation to methyltransferase activity (Comment on DOI 10.1002/bies.201300088). Bioessays. 2013 Dec;35(12):1024. PMID: 24242100

 

 

  • Girardot M, Hirasawa R, Kacem S, Fritsch L, Pontis J, Kota SK, Filipponi D, Fabbrizio E, Sardet C, Lohmann F, Kadam S, Ait-Si-Ali S, Feil R. PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome. Nucleic Acids Res. 2014 Jan;42(1):235-48. PMID: 24097435
  • Vallot C, Rougeulle C. Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome. RNA Biol. 2013 Aug;10(8):1262-5. PMID: 23948700

 

 

  • Kasprzyk L, Defossez PA, Miotto B. [Epigenetic regulation in neuronal differentiation and brain function]. Biol Aujourdhui. 2013;207(1):1-17. PMID: 23694721
  • Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman JB. Theileria induces oxidative stress and HIF1α activation that are essential for host leukocyte transformation. Oncogene. 2014 Apr 3;33(14):1809-17. PMID: 23665677
  • Marsolier J, Pineau S, Medjkane S, Perichon M, Yin Q, Flemington E, Weitzman MD, Weitzman JB. OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. PLoS Pathog. 2013;9(4):e1003222. PMID: 23637592
  • Petersen E. Bad & breakfast. Interview by Sophia Häfner. Microbes Infect. 2013 Jun;15(6-7):531-3. PMID: 23624106
  • Polo SE. Fine-tuning the p53 response to DNA damage: a new piece in the puzzle. Cell Cycle. 2013 May 1;12(9):1337-8. PMID: 23588075
  • Häfner S. Tuning the immune system. Microbes Infect. 2013 May;15(5):339-41. PMID: 23474332
  • Cramer RA, Hohl TM. Some fungi in the air. Interview by Sophia Häfner. Microbes Infect. 2013 Apr;15(4):255-8. PMID: 23376622
  • Häfner S. SARS attacks! Microbes Infect. 2013 Feb;15(2):85-7. PMID: 23262187
  • Weitzman J. Epigenetics in health and disease. Joint Bone Spine. 2012 Dec;79(6):565.PMID: 23177914
  • Häfner S. Sending out an ExoS–eyes kept on Pseudomonas. Microbes Infect. 2012 Dec;14(15):1363-5. PMID: 23142033
  • Häfner S, Weitzman J. Of mice and men–NAIP homologues face Legionella pneumophila. Microbes Infect. 2012 Nov;14(13):1119-22. PMID: 22922068
  • Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, Chluba J, Langsley G, Weitzman JB. SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res. 2012 Feb 1;72(3):810-20. PMID: 22194464
  • Fournier A, Sasai N, Nakao M, Defossez PA. The role of methyl-binding proteins in chromatin organization and epigenome maintenance. Brief Funct Genomics. 2012 May;11(3):251-64. PMID: 22184333
  • Romito A, Rougeulle C. Origin and evolution of the long non-coding genes in the X-inactivation center. Biochimie. 2011 Nov;93(11):1935-42. PMID: 21820484
  • Ulveling D, Francastel C, Hub&eacute F. Identification of potentially new bifunctional RNA based on genome-wide data-mining of alternative splicing events. Biochimie. 2011 Nov;93(11):2024-7. PMID: 21729736
  • Defossez PA, Stancheva I. Biological functions of methyl-CpG-binding proteins. Prog Mol Biol Transl Sci. 2011;101:377-98. PMID: 21507359
  • Makhlouf M, Rougeulle C. Linking X chromosome inactivation to pluripotency: Necessity or fate? Trends Mol Med. 2011 Jun;17(6):329-36. PMID: 21411371
  • Ulveling D, Francastel C, Hub&eacute F. When one is better than two: RNA with dual functions. Biochimie. 2011 Apr;93(4):633-44. PMID: 21111023
  • Guillemin C, Francastel C. [Heterochromatin compartments and gene silencing: human hematopoietic differentiation as a model study]. Biol Aujourdhui. 2010;204(3):221-33. PMID: 20950566
  • Abane R, Mezger V. Roles of heat shock factors in gametogenesis and development. FEBS J. 2010 Oct;277(20):4150-72. PMID: 20945531
  • Joulie M, Miotto B, Defossez PA. Mammalian methyl-binding proteins: what might they do? Bioessays. 2010 Dec;32(12):1025-32. PMID: 20886526
  • Hub&eacute F, Velasco G, Rollin J, Furling D, Francastel C. Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. Nucleic Acids Res. 2011 Jan;39(2):513-25. PMID: 20855289
  • Miotto B, Graba Y. Control of DNA replication: a new facet of Hox proteins? Bioessays. 2010 Sep;32(9):800-7. PMID: 20730947
  • Sasai N, Nakao M, Defossez PA. Sequence-specific recognition of methylated DNA by human zinc-finger proteins. Nucleic Acids Res. 2010 Aug;38(15):5015-22. PMID: 20403812
  • Navarro P, Chantalat S, Foglio M, Chureau C, Vigneau S, Clerc P, Avner P, Rougeulle C. A role for non-coding Tsix transcription in partitioning chromatin domains within the mouse X-inactivation centre. Epigenetics Chromatin. 2009 Jul 20;2(1):8. PMID: 19615107