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Pierre CARON
Post-Doctoral fellow (FRM)
Equipe : intégrité de l épigenome
Téléphone : +33 1 57 27 89 81
Pièce n°: 413
Pierre joined Sophie Polo’s Lab in April 2019 as a postdoctoral researcher. During his PhD in the laboratory of Gaëlle Legube (University Paul Sabatier, Toulouse, France), he worked on the establishment of a human cell line in which sequence-specific DNA double-strand breaks (DSBs) can be induced throughout the entire genome. Using this model, he generated the high-resolution map of a DNA damage-induced chromatin modification (γH2A.X) and identified key determinants that affect the distribution of this histone mark throughout damaged chromatin. He then moved to Haico van Attikum’s laboratory (Leiden University Medical Center, the Netherlands) with the support of an EMBO postdoctoral fellowship. There, he unveiled a role for the ubiquitin ligase WWP2 in coordinating transcription repression and DSB repair by targeting RNAPII large subunit for proteasomal degradation. In Sophie Polo’s laboratory, Pierre is studying the mechanisms protecting genome integrity and the epigenetic landscape in response to DNA damage arising in heterochromatin domains.

SELECTED PUBLICATIONS

  • Caron P.*, Pobega E.*, Polo S.E.. DNA double-strand break repair: All roads lead to heterochROMAtin marks. Front Genet, 12: 730696, 2021. *: equal contribution
  • Caron P., Pobega E., Polo S.E. A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks. Mol Cell, 81:2059-2060, 2021
  • Fortuny A., Chansard A., Caron P., Chevallier O., Leroy O., Renaud O., Polo S.E. Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance. Nat Commun, 12:2428, 2021.
  • Caron P., Polo S.E. Reshaping Chromatin Architecture around DNA Breaks. Trends Biochem Sci, 45: 177-179, 2020.
  • Caron P.*, Pankotai T.*, Wiegant W.W., Tollenaere M.A.X., Furst A., Bonhomme C., Helfricht A., de Groot A., Pastink A., Vertegaal A.C.O., Luijsterburg M.S., Soutoglou E.§, van Attikum H.§. WWP2 ubiquitylates RNAPII for DNA-PK-dependent transcription arrest and repair at DNA breaks. Genes & Dev, 33: 684-704, 2019. *equal contribution. §corresponding authors.
  • Caron P., van der Linden J., van Attikum H. Bon voyage: a transcriptional journey around DNA breaks. DNA Repair, 82: 102686, 2019.
  • Caron P.*, Choudjaye J.*, Clouaire T., Bugler B., Daburon V., Aguirrebengoa M., Mangeat T., Iacovoni J.S., Cortés-Ledesma F., Legube G. Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks Cell Reports, 13: 1598-1609, 2015. *equal contribution.
  • Zhou Y., Caron P., Legube G., Paull T.T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res, 42: e19, 2014.
  • Caron P., Aymard F., Iacovoni J.S., Briois S., Canitrot Y., Bugler B., Massip L., Losada A., Legube G. Cohesin protects genes against γH2AX Induced by DNA double-strand breaks. PLoS Genet, 8: e1002460, 2012.
  • Massip L., Caron P., Iacovoni J.S., Trouche D., Legube G. Deciphering the chromatin landscape induced around DNA double strand breaks. Cell Cycle, 9: 2963-72, 2010.
  • Iacovoni J.S.*, Caron P.*, Lassadi I., Nicolas E., Massip L., Trouche D., Legube G. High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J, 29: 1446-57,2010. *equal contribution