keyboard_arrow_leftRetour
 Pierre CARON Post-Doctoral fellow (FRM) Equipe : intégrité de l épigenome | Téléphone : +33 1 57 27 89 81 Pièce n°: 413 |
| Pierre joined Sophie Polo’s Lab in April 2019 as a postdoctoral researcher. During his PhD in the laboratory of Gaëlle Legube (University Paul Sabatier, Toulouse, France), he worked on the establishment of a human cell line in which sequence-specific DNA double-strand breaks (DSBs) can be induced throughout the entire genome. Using this model, he generated the high-resolution map of a DNA damage-induced chromatin modification (γH2A.X) and identified key determinants that affect the distribution of this histone mark throughout damaged chromatin. He then moved to Haico van Attikum’s laboratory (Leiden University Medical Center, the Netherlands) with the support of an EMBO postdoctoral fellowship. There, he unveiled a role for the ubiquitin ligase WWP2 in coordinating transcription repression and DSB repair by targeting RNAPII large subunit for proteasomal degradation. In Sophie Polo’s laboratory, Pierre is studying the mechanisms protecting genome integrity and the epigenetic landscape in response to DNA damage arising in heterochromatin domains. SELECTED PUBLICATIONS
| |