People | UMR7216 – Paris Epigenetics

Olivier KIRSH

Lecturer - Maître de conférence

Equipe : Dynamique de la Méthylation de l’ADN des Génomes Eucaryotes

Pièce n°: 329

Olivier Kirsh is Maître de Conférence (Lecturer /Associate Professor) at the Université Paris Diderot / USPC / Université de Paris.

He’s teaching biostatistics, molecular biology, functional genomic and bio-informatics from L1 to M2 at Univertsité de PARIS (Paris – Diderot, Paris 7). He’s regulary invited in panels (Magistere de Génétique, Master BI, Ecole Doctorale Compléxité du Vivant, Ecole Doctorale HOB, comité de Thèse, Comité de sélection de Maître de Conférence…). He’s also teaching for « formation continue » at the Cancéropole, l\\\'école de bioinformatique AVIESAN de Roscoff and for the DU « Bioinformatique intégrative ». He co-animate the “Paris 7 Bioinfo Club” on the Paris Rive Gauche Campus.

In september 2013, Olivier joined Pierre-Antoine Defossez’s team to deploy bio-informatics and bio-analyses approaches (Nanostring, ChIP-seq, RNA-seq, microarray, Whole Genome and Reduced Representation of Bisulfite Sequencing (WGBS & RRBS analyses)) to study the interplay between kinases signaling pathways, chromatin remodelers and DNA methylation for the control of gene expression in cancer cell and during mouse embryonic stem cells differentiation. He’s a member (comité de pilotage) of our Bioinformatic platform. He develops pipelines and scripts used to explore and analyse experiments implementing high-throughput sequencing technologies. His daily tools are R, Bash or Docker /Singularity to run computational analyses on our cluster or on ifb servers.

Former activities:

He did his PhD at the Institut PASTEUR in Dr Anne Dejean’s lab (Unité d’Organisation Nucléaire et Oncogenèse) working on SUMO, a new Ubiquitin-like post-translational modification and senescence. He did a postdoctoral training at the Institut de Recherches Cliniques de Montréal (IRCM) in the laboratory of molecular genetics of Dr Jacques Drouin where he worked on the molecular mechanisms of nuclear receptors transcriptional repression. Then he moved to the Institut de Génétique Moléculaire de Montpellier (IGMM) in Dr Claude Sardet’s lab where he developed bio-informatics and high-throughput sequencing technologies approaches to characterized the E4F1 transcription factor target genes. His contribution enlightens unexpected functions linking cell cycle, genome integrity and metabolism for this transcription factor in cancer and post mitotics cells. He also worked with Dr Eric Julien on the H4K20me1 epigenetic mark involved in replication origins licensing.

Links:

https://www.researchgate.net/profile/Olivier_Kirsh
http://parisepigenetics.com/people/?member=109
http://parisepigenetics.com/dmdeg/
https://www.mendeley.com/profiles/olivier-kirsh/
https://github.com/kirsho
https://hub.docker.com/u/okirsh
https://anaconda.org/okirsh

ORCID ID : 0000-0001-6200-568 1 Scopus Author ID : 6 507174606

Publications :

https://www.ncbi.nlm.nih.gov/pubmed/?term=kirsh+O

Items: 19

AP-1 signaling by Fra-1 directly regulates HMGA1 oncogene transcription in Triple Negative Breast Cancers.

Tolza C, Bejjani F, Evanno E, Mahfoud S, Moquet-Torcy G, Gostan T, Maqbool MA, Kirsh O, Piechaczyk M, Jariel-Encontre I.

Mol Cancer Res. 2019 Jul 12. pii: molcanres.0036.2019. doi: 10.1158/1541-7786.MCR-19-0036. [Epub ahead of print]

PMID: 31300541