Olivier KIRSH Lecturer - Maître de conférence Equipe : Dynamique de la Méthylation de l’ADN des Génomes Eucaryotes | Email : olivier.kirsh@u-paris.fr Pièce n°: 329 |
Olivier Kirsh is Maître de Conférence (Lecturer /Associate Professor) at the Université Paris Diderot / USPC / Université de Paris. He’s teaching biostatistics, molecular biology, functional genomic and bio-informatics from L1 to M2 at Univertsité de PARIS (Paris – Diderot, Paris 7). He’s regulary invited in panels (Magistere de Génétique, Master BI, Ecole Doctorale Compléxité du Vivant, Ecole Doctorale HOB, comité de Thèse, Comité de sélection de Maître de Conférence…). He’s also teaching for « formation continue » at the Cancéropole, l\\\'école de bioinformatique AVIESAN de Roscoff and for the DU « Bioinformatique intégrative ». He co-animate the “Paris 7 Bioinfo Club” on the Paris Rive Gauche Campus. In september 2013, Olivier joined Pierre-Antoine Defossez’s team to deploy bio-informatics and bio-analyses approaches (Nanostring, ChIP-seq, RNA-seq, microarray, Whole Genome and Reduced Representation of Bisulfite Sequencing (WGBS & RRBS analyses)) to study the interplay between kinases signaling pathways, chromatin remodelers and DNA methylation for the control of gene expression in cancer cell and during mouse embryonic stem cells differentiation. He’s a member (comité de pilotage) of our Bioinformatic platform. He develops pipelines and scripts used to explore and analyse experiments implementing high-throughput sequencing technologies. His daily tools are R, Bash or Docker /Singularity to run computational analyses on our cluster or on ifb servers. Former activities: He did his PhD at the Institut PASTEUR in Dr Anne Dejean’s lab (Unité d’Organisation Nucléaire et Oncogenèse) working on SUMO, a new Ubiquitin-like post-translational modification and senescence. He did a postdoctoral training at the Institut de Recherches Cliniques de Montréal (IRCM) in the laboratory of molecular genetics of Dr Jacques Drouin where he worked on the molecular mechanisms of nuclear receptors transcriptional repression. Then he moved to the Institut de Génétique Moléculaire de Montpellier (IGMM) in Dr Claude Sardet’s lab where he developed bio-informatics and high-throughput sequencing technologies approaches to characterized the E4F1 transcription factor target genes. His contribution enlightens unexpected functions linking cell cycle, genome integrity and metabolism for this transcription factor in cancer and post mitotics cells. He also worked with Dr Eric Julien on the H4K20me1 epigenetic mark involved in replication origins licensing.
Links: https://www.researchgate.net/profile/Olivier_Kirsh http://parisepigenetics.com/people/?member=109 http://parisepigenetics.com/dmdeg/ https://www.mendeley.com/profiles/olivier-kirsh/ ORCID ID : 0000-0001-6200-5681 Scopus Author ID : 6507174606 Publications : https://www.ncbi.nlm.nih.gov/pubmed/?term=kirsh+O Items: 191. Tolza C, Bejjani F, Evanno E, Mahfoud S, Moquet-Torcy G, Gostan T, Maqbool MA, Kirsh O, Piechaczyk M, Jariel-Encontre I. Mol Cancer Res. 2019 Jul 12. pii: molcanres.0036.2019. doi: 10.1158/1541-7786.MCR-19-0036. [Epub ahead of print] PMID: 31300541 2. Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O*, Defossez PA*. Nucleic Acids Res. 2019 Apr 23;47(7):3407-3421. doi: 10.1093/nar/gkz080. PMID: 30753595 3. Mechanisms of DNA Methyltransferase Recruitment in Mammals. Laisné M, Gupta N, Kirsh O, Pradhan S, Defossez PA. Genes (Basel). 2018 Dec 10;9(12). pii: E617. doi: 10.3390/genes9120617. Review. PMID: 30544749 4. The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D. Aging Cell. 2018 Dec;17(6):e12831. doi: 10.1111/acel.12831. Epub 2018 Sep 14. PMID: 30216632 5. [Unexpected roles for a methyl-binding protein in cancer]. Naciri I, Roussel-Gervais A, Defossez PA, Kirsh O. Med Sci (Paris). 2017 Aug-Sep;33(8-9):714-716. doi: 10.1051/medsci/20173308009. Epub 2017 Sep 18. French. No abstract available. PMID: 28945554 6. Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA. Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10. PMID: 28803780 7. Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4. PMID: 27815388 8. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Lacroix M*, Rodier G*, Kirsh O*, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais JC, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. doi: 10.1073/pnas.1602754113. Epub 2016 Sep 12. PMID: 27621446 9. E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis. Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. doi: 10.1073/pnas.1602751113. Epub 2016 Sep 12. PMID: 27621431 10. Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D. Aging (Albany NY). 2015 Nov;7(11):986-1003. PMID: 26583757 11. Houlès T, Rodier G, Le Cam L, Sardet C, Kirsh O. Genom Data. 2015 Jul 14;5:368-70. doi: 10.1016/j.gdata.2015.07.004. eCollection 2015 Sep. PMID: 26484288 12. The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions. Rodier G*, Kirsh O*, Baraibar M, Houlès T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C. Cell Rep. 2015 Apr 14;11(2):220-33. doi: 10.1016/j.celrep.2015.03.024. Epub 2015 Apr 2. PMID: 25843721 13. E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells. Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L. J Exp Med. 2011 Jul 4;208(7):1403-17. doi: 10.1084/jem.20101995. Epub 2011 Jun 27. PMID: 21708927 14. Brustel J, Tardat M, Kirsh O, Grimaud C, Julien E. Trends Cell Biol. 2011 Aug;21(8):452-60. doi: 10.1016/j.tcb.2011.04.006. Epub 2011 May 31. Review. PMID: 21632252 15. The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E. Nat Cell Biol. 2010 Nov;12(11):1086-93. doi: 10.1038/ncb2113. Epub 2010 Oct 17. PMID: 20953199 16. FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family. van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J. J Biol Chem. 2005 Nov 11;280(45):38035-46. Epub 2005 Sep 7. PMID: 16148010 17. Tallec LP, Kirsh O, Lecomte MC, Viengchareun S, Zennaro MC, Dejean A, Lombès M. Mol Endocrinol. 2003 Dec;17(12):2529-42. Epub 2003 Sep 18. PMID: 14500761 18. Deconstructing PML-induced premature senescence. Bischof O, Kirsh O, Pearson M, Itahana K, Pelicci PG, Dejean A. EMBO J. 2002 Jul 1;21(13):3358-69. PMID: 12093737 19. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. Kirsh O*, Seeler JS*, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A. EMBO J. 2002 Jun 3;21(11):2682-91. PMID: 12032081 Thesis : Kirsh O sous la direction de Anne Dejean-Assemat 24/11/2003, Paris 11 Chapitres d\\\'ouvrage: ÉPIGÉNÉTIQUE. Naciri I, Defossez PA, Kirsh O. La science au présent, 2017 ÉPIGÉNÉTIQUE. Naciri I, Defossez PA, Kirsh O. Encyclopædia Universalis 2016. |
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