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Olivier KIRSH
Lecturer - Maître de conférence
Equipe : Dynamique de la Méthylation de l’ADN des Génomes Eucaryotes
Téléphone : +33 (0)1 57 27 89 26
Pièce n°: 438

Olivier Kirsh is Maître de Conférence (Lecturer /Associate Professor) at the Université Paris Diderot / USPC / Université de Paris.

He’s teaching biostatistics, molecular biology, functional genomic and bio-informatics from L1 to M2 at Univertsité de PARIS (Paris – Diderot, Paris 7). He’s regulary invited in panels (Magistere de Génétique, Master BI, Ecole Doctorale Compléxité du Vivant, Ecole Doctorale HOB, comité de Thèse, Comité de sélection de Maître de Conférence…). He’s also teaching for « formation continue » at the Cancéropole, l'école de bioinformatique AVIESAN de Roscoff and for the DU « Bioinformatique intégrative ». He co-animate the “Paris 7 Bioinfo Club” on the Paris Rive Gauche Campus.

In september 2013, Olivier joined Pierre-Antoine Defossez’s team to deploy bio-informatics and bio-analyses approaches (Nanostring, ChIP-seq, RNA-seq, microarray, Whole Genome and Reduced Representation of Bisulfite Sequencing (WGBS & RRBS analyses)) to study the interplay between kinases signaling pathways, chromatin remodelers and DNA methylation for the control of gene expression in cancer cell and during mouse embryonic stem cells differentiation. He’s a member (comité de pilotage) of our Bioinformatic platform. He develops pipelines and scripts used to explore and analyse experiments implementing high-throughput sequencing technologies. His daily tools are R, Bash or Docker /Singularity to run computational analyses on our cluster or on ifb servers.

Former activities:

He did his PhD at the Institut PASTEUR in Dr Anne Dejean’s lab (Unité d’Organisation Nucléaire et Oncogenèse) working on SUMO, a new Ubiquitin-like post-translational modification and senescence. He did a postdoctoral training at the Institut de Recherches Cliniques de Montréal (IRCM) in the laboratory of molecular genetics of Dr Jacques Drouin where he worked on the molecular mechanisms of nuclear receptors transcriptional repression. Then he moved to the Institut de Génétique Moléculaire de Montpellier (IGMM) in Dr Claude Sardet’s lab where he developed bio-informatics and high-throughput sequencing technologies approaches to characterized the E4F1 transcription factor target genes. His contribution enlightens unexpected functions linking cell cycle, genome integrity and metabolism for this transcription factor in cancer and post mitotics cells. He also worked with Dr Eric Julien on the H4K20me1 epigenetic mark involved in replication origins licensing.



Links:

ORCID ID : 0000-0001-6200-5681 Scopus Author ID : 6507174606


Publications :

https://www.ncbi.nlm.nih.gov/pubmed/?term=kirsh+O

Items: 19

1.

AP-1 signaling by Fra-1 directly regulates HMGA1 oncogene transcription in Triple Negative Breast Cancers.

Tolza C, Bejjani F, Evanno E, Mahfoud S, Moquet-Torcy G, Gostan T, Maqbool MA, Kirsh O, Piechaczyk M, Jariel-Encontre I.

Mol Cancer Res. 2019 Jul 12. pii: molcanres.0036.2019. doi: 10.1158/1541-7786.MCR-19-0036. [Epub ahead of print]

PMID: 31300541

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2.

Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.

Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O*, Defossez PA*.

Nucleic Acids Res. 2019 Apr 23;47(7):3407-3421. doi: 10.1093/nar/gkz080.

PMID: 30753595 

Free PMC Article

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3.

Mechanisms of DNA Methyltransferase Recruitment in Mammals.

Laisné M, Gupta N, Kirsh O, Pradhan S, Defossez PA.

Genes (Basel). 2018 Dec 10;9(12). pii: E617. doi: 10.3390/genes9120617. Review.

PMID: 30544749 

Free PMC Article

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4.

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D.

Aging Cell. 2018 Dec;17(6):e12831. doi: 10.1111/acel.12831. Epub 2018 Sep 14.

PMID: 30216632 

Free PMC Article

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5.

[Unexpected roles for a methyl-binding protein in cancer].

Naciri I, Roussel-Gervais A, Defossez PA, Kirsh O.

Med Sci (Paris). 2017 Aug-Sep;33(8-9):714-716. doi: 10.1051/medsci/20173308009. Epub 2017 Sep 18. French. No abstract available.

PMID: 28945554 

Free Article

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6.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

PMID: 28803780 

Free Article

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7.

Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA.

Cancer Res. 2017 Jan 1;77(1):62-73. doi: 10.1158/0008-5472.CAN-16-1181. Epub 2016 Nov 4.

PMID: 27815388 

Free Article

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8.

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.

Lacroix M*, Rodier G*, Kirsh O*, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais JC, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. doi: 10.1073/pnas.1602754113. Epub 2016 Sep 12.

PMID: 27621446 

Free PMC Article

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9.

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. doi: 10.1073/pnas.1602751113. Epub 2016 Sep 12.

PMID: 27621431 

Free PMC Article

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10.

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program.

Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA, Bernard D.

Aging (Albany NY). 2015 Nov;7(11):986-1003.

PMID: 26583757 

Free PMC Article

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11.

Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs.

Houlès T, Rodier G, Le Cam L, Sardet C, Kirsh O.

Genom Data. 2015 Jul 14;5:368-70. doi: 10.1016/j.gdata.2015.07.004. eCollection 2015 Sep.

PMID: 26484288 

Free PMC Article

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12.

The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.

Rodier G*, Kirsh O*, Baraibar M, Houlès T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C.

Cell Rep. 2015 Apr 14;11(2):220-33. doi: 10.1016/j.celrep.2015.03.024. Epub 2015 Apr 2.

PMID: 25843721 

Free Article

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13.

E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.

Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L.

J Exp Med. 2011 Jul 4;208(7):1403-17. doi: 10.1084/jem.20101995. Epub 2011 Jun 27.

PMID: 21708927 

Free PMC Article

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14.

Coupling mitosis to DNA replication: the emerging role of the histone H4-lysine 20 methyltransferase PR-Set7.

Brustel J, Tardat M, Kirsh O, Grimaud C, Julien E.

Trends Cell Biol. 2011 Aug;21(8):452-60. doi: 10.1016/j.tcb.2011.04.006. Epub 2011 May 31. Review.

PMID: 21632252

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15.

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.

Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E.

Nat Cell Biol. 2010 Nov;12(11):1086-93. doi: 10.1038/ncb2113. Epub 2010 Oct 17.

PMID: 20953199

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16.

FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.

van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J.

J Biol Chem. 2005 Nov 11;280(45):38035-46. Epub 2005 Sep 7.

PMID: 16148010 

Free Article

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17.

Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification.

Tallec LP, Kirsh O, Lecomte MC, Viengchareun S, Zennaro MC, Dejean A, Lombès M.

Mol Endocrinol. 2003 Dec;17(12):2529-42. Epub 2003 Sep 18.

PMID: 14500761

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18.

Deconstructing PML-induced premature senescence.

Bischof O, Kirsh O, Pearson M, Itahana K, Pelicci PG, Dejean A.

EMBO J. 2002 Jul 1;21(13):3358-69.

PMID: 12093737 

Free PMC Article

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19.

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

Kirsh O*, Seeler JS*, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A.

EMBO J. 2002 Jun 3;21(11):2682-91.

PMID: 12032081 

Free PMC Article

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Thesis :


Etude de la voie de modification post-traductionnelle SUMO : implication dans la régulation transcriptionnelle

Kirsh O sous la direction de Anne Dejean-Assemat

24/11/2003, Paris 11



Chapitres d'ouvrage:


ÉPIGÉNÉTIQUE.

Naciri I, Defossez PA, Kirsh O.

La science au présent, 2017


ÉPIGÉNÉTIQUE.

Naciri I, Defossez PA, Kirsh O.

Encyclopædia Universalis 2016.