Epigénétique et Destin Cellulaire


The Epigenetics and Cell Fate Centre is seeking to recruit two talented junior and/or senior group leaders

The Epigenetics and Cell Fate Centre is a leading institute exploring cell identity and diversity in physiological and pathological contexts....
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Congratulations to the Weitzman team for its FRM certification as an “Équipe FRM”

Congratulations to Jonathan Weitzman’s team for being selected by the Équipes FRM program of La Fondation pour la Recherche Médicale....
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Intervention by Marie and Aurélie during Pint of Science 2022 «What is happening in our cells?»

On the occasion of the opening of Pint of Science 2022 on the theme "What is happening in our cells?"...
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Wednesday May 4th 2022 11:00 Jamie HACKETT EMBL Monterotondo Invite by Claire Rougeulle Epigenetic Inheritance: from Phenotype Variation to Mechanisms
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Wednesday April 27th 2022 11:00 Karine AUDOUZE SysTox group, Univ. Paris Cité campus St Peres Invited by Valérie Mezger Artificial...
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Wednesday April 20th 2022 11:00 Jussi TAIPALE University of Oxford Invited by Pierre Defossez Transcriptional Control of Growth https://u-paris.zoom.us/j/86114422072?pwd=VzJ0c2pxcHl4OWppekx3MldlM2Y4QT09 ID...
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Wednesday April 13th 2022 11:00 Judith MINE-HATTAB Institut Curie Invited by Audrey Chansard Single molecule microscopy reveals key physical features...
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Thursday 7 march 2022 16:00 Peter LEWIS Univ. Wisconsin-Madison Invited by Sophie Polo Misregulation of Polucomb Repressive Complex 2 Activity...
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Unit retreat (Sainte Montaine October 2021)

The UMR7216 « Epigenetics and Cell Fate » is a joint research department supported by CNRS and Université de Paris. It was created in 2009 on the Paris Diderot Rive-Gauche campus to create a dynamic environment for research, teaching and training in epigenetics research, focusing on mechanistic understanding of processes that govern cellular identity or are altered in disease states.

The department is composed of 7 teams  with shared interest in epigenetic regulation and in dissecting epigenetic mechanisms, broadly focusing on (i) DNA methylation and its machinery, (ii) histone marks and chromatin structure, (iii) short and long non-coding RNA as either drivers or readouts of cellular states, (iv) chromosomes and nuclear organization as determinants of gene regulation programs and (v) responses to cellular and genotoxic stress at the level of genome integrity and transcription. Research teams combine functional (epi)genomics, (epi)genomic engineering, biochemistry, live microscopy and cell biology approaches, creating a solid network of complementary expertise to decode key mechanistic aspects of epigenetic mechanisms, their dynamics, their implication in development and differentiation processes and their contribution to pathological processes.

The department has developed on-site technical platforms for Functional Epigenomics, Fluorescence microscopy and a Vectorology including a confined L3 tissue culture room, with state-of-the-art equipment and staffed with specialized and experienced technicians who assist the researchers to achieve the desired goals.

Members of the department are also deeply involved in teaching, mentoring and research training for students and young scientists at the heart of a dynamic university campus.

We are committed to support collaboration and scientific animation with other research structures on campus (IJM, BFA, MSC) and off campus and to promote a common scientific strategy at the interface between functional, chemical and structural biology disciplines.

Overall, UMR 7216 is composed of about 60 researchers, lecturers, post-docs, doctoral students, engineers, technicians and administrative staff. The combination with technical platforms and access to the campus scientific equipment and technological core facilities provides a working environment that fosters research excellence. Our department belongs to excellence scientific networks (Labex Who Am I?; DHU PROTECT).

Organization chart

The Direction

The Principal Investigators