Epigénétique et Destin Cellulaire


Congratulation to Aurélie de Thonel, Délara Sabéran-Djoneidi and Valérie Mezger for their article

Congratulation to Aurélie de Thonel, Délara Sabéran-Djoneidi and Valérie Mezger for their article: Heat Shock Factor 2 Protects against Proteotoxicity...
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Congratulation to Céline MOREY

Congratulation to Céline Morey for her special issue in "Frontiers in Cell and Developmental Biology, section Developmental Epigenetics" and entitled...
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Baptiste Bogard won the first prize for the oral presentation of young researchers at the 2019 Myology Meeting

Baptiste Bogard won the first prize for the oral presentation of young researchers at the 2019 Myology Meeting Watch the...
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The center for Epigenetics and Cell Fate celebrates its first decade

The Centre for Epigenetics and Cell Fate (UMR 7216 Epigénétique et Destin Cellulaire) was created in 2009 by the Université...
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5 new Doctors ès Sciences

And here we have five more new Ph.D! They have defended (only girls!) all last week! Congratulations ladies!!!!
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Congratulations !!!!

4 new students got their PhD fellowships from the Ministère de la Recherche this year again !!!! Congratulations to Gilles,...
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Call for papers : Intron-centric transcription and its role in normal physiology and disease

Call for papers at 'Frontiers in Genetics & Frontiers in Molecular Biosciences section RNA' for a special issue : 'Intron-centric...
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Call for papers : Genetics and Epigenetics, who decides ?

Cited by index medicus, MEDLINE, Current Contents, Swets-Blakwell, BIOSIS and chemical abstracts   Stéphane Jamain (Managing editor) stephane.jamain@inserm.fr Florent Hubé...
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Graduate School G.E.N.E.

Thanks to the joint efforts of Professors Jonathan Weitzman and Alain Zider, the Graduate School G.E.N.E has been selected for...
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EMBO Young Investigator

October 25th: Sophie has been selected to join the EMBO Young Investigator Programme: great news!
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Rosemary KIERNAN

Wednesday February 26 2020 11:00 Rosemary KIERNAN IGH Montpellier Invited by Baptiste Bogard NF90-Dependent Regulation of miRNA Expression in Cancer...
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Camille Lobry

Wednesday February 5 2020 11:00 Camille Lobry Institut Gustave Roussy, Villejuif Invited by Céline Morey Non-coding Genome and Epigenetic Regulation...
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Tuncay Baubec

Wednesday January 22 2020 11:00 Tuncay Baubec University of Zurich, Switzerland Invited by Alexandre, Polo team Disentangling protein-chromatin interactions at...
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Agnese Loda

Wednesday January 15 2020 11:00 Agnese Loda EMBL Invited by Emmanuel Cazottes and Claire Rougeulle Functional Dissection of X-linked Regulatory...
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Dennis Thiele

Wednesday December 18 11:00 Dennis Thiele Duke University School of Medicine, North Carolina, USA Invited by Valérie Mezger Targeting Heat...
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Angel Barco

Wednesday December 11 11:00 Angel Barco Alicante, Spain Invited by Valérie Mezger Epigenetic Etiology of Intellectual Disability Buffon Building RB-18B...
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Rosemary KIERNAN (Unscheduled)

Wednesday November 27 11:00 Rosemary KIERNAN (Unscheduled) IGH, Montpellier Invited by Baptiste Bogard TBA Buffon Building RB-18B (Wing B -...
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Valeria Naim

Wednesday October 16 11:00 Valeria Naim IGR, Villejuif Invited by Beatrice RONDINELLI and Sophie POLO OGM Buffon Building RB-18B (Wing...
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Christian Bleux

Wednesday November 13 11:00 Christian Bleux Invited by Christophe Huret OGM Buffon Building RB-18B (Wing B - RdC bas) 15...
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Nicolas Carpi

Wednesday October 30 11:00 Nicolas Carpi Institut Curie Invited by Pierre-Antoine Defossez and Olivier Kirsh Electronic lab book elabFTW Buffon...
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10 years celebration of the Unit  (May 2019)

The UMR7216 « Epigenetics and Cell Fate » is a joint research department supported by CNRS and Université de Paris. It was created in 2009 on the Paris Diderot Rive-Gauche campus to create a dynamic environment for research, teaching and training in epigenetics research, focusing on mechanistic understanding of processes that govern cellular identity or are altered in disease states.

The department is composed of 7 teams  with shared interest in epigenetic regulation and in dissecting epigenetic mechanisms, broadly focusing on (i) DNA methylation and its machinery, (ii) histone marks and chromatin structure, (iii) short and long non-coding RNA as either drivers or readouts of cellular states, (iv) chromosomes and nuclear organization as determinants of gene regulation programs and (v) responses to cellular and genotoxic stress at the level of genome integrity and transcription. Research teams combine functional (epi)genomics, (epi)genomic engineering, biochemistry, live microscopy and cell biology approaches, creating a solid network of complementary expertise to decode key mechanistic aspects of epigenetic mechanisms, their dynamics, their implication in development and differentiation processes and their contribution to pathological processes.

The department has developed on-site technical platforms for Functional Epigenomics, Fluorescence microscopy and a Vectorology including a confined L3 tissue culture room, with state-of-the-art equipment and staffed with specialized and experienced technicians who assist the researchers to achieve the desired goals.

Members of the department are also deeply involved in teaching, mentoring and research training for students and young scientists at the heart of a dynamic university campus.

We are committed to support collaboration and scientific animation with other research structures on campus (IJM, BFA, MSC) and off campus and to promote a common scientific strategy at the interface between functional, chemical and structural biology disciplines.

Overall, UMR 7216 is composed of about 60 researchers, lecturers, post-docs, doctoral students, engineers, technicians and administrative staff. The combination with technical platforms and access to the campus scientific equipment and technological core facilities provides a working environment that fosters research excellence. Our department belongs to excellence scientific networks (Labex Who Am I?; DHU PROTECT).

Organization chart

The Direction

The Principal Investigators