1. Essential cytoplasmic role of the histone lysine methyltransferase Setdb1 in post-transcriptional regulation in embryonic stem cells. Rapone R, Del Maestro L, Bouyioukos C, Albini S, Cruz-Tapias P, Joliot V, Cosson B, Ait-Si-Ali S (2021). Preprint: Rapone et al., Res Sq


  1. SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties. Nucleic Acids Research, 2022 (accepted). Zakharova VV, Magnitov MD, Del Maestro L, Ulianov SV, Glentis A, Ulyanik B, Williart A, Karpukhina A, Demidov O, Joliot V, Vassetzky YS, Mège RM, Piel M, Razin SV & Ait-Si-Ali S. PMID: 35474385
  2. Paramecium Polycomb Repressive Complex 2 physically interacts with the small RNA binding PIWI protein to repress transposable elements. Developmental Cell, 2022 (accepted). Miró Pina C, Charmant O, Kawaguchi T, Holoch D, Michaud A, Cohen I, Humbert A, Jaszczyszyn Y, Chevreux G, Del Maestro L, Ait-Si-Ali S, Arnaiz O, Margueron R, Duharcourt S. PMID: 35429435


  1. Acute conversion of patient-derived Duchenne Muscular Dystrophy iPSC into myotubes, reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling. Skeletal Muscle, 2020. L Caputo, A Granados, J Lenzi, A Rosa, S Ait-Si-Ali, PL Puri & S Albini. PMID: 32359374
  2. The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma. Liver international, 2020. N Poté, J Cros, S Laouirem, J Raffenne, M Negrão, M Albuquerque, P Bedossa, MG Ferreira, S Ait-Si-Ali, R Fior and V Paradis. PMID: 31943753


  1. The H3K9 Methylation Writer SETDB1 and Its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells. Genes, 2019. Cruz-Tapias P, Robin P, Pontis J, Del Maestro L, Ait-Si-Ali S. PMID: 31557926
  2. Expression of the Major and Pro-Oncogenic H3K9 Lysine Methyltransferase SETDB1 in Non-Small Cell Lung Cancer. Cancers, 2019. Cruz-Tapias P, Zakharova V, Perez-Fernandez OM, Mantilla W, Ramírez-Clavijo S, Ait-Si-Ali S. PMID: 31398867
  3. Histone modifications. Book chapter in Epigenetics and Regeneration by Elsevier, 2019. Albini S, Zakharova V, Ait-Si-Ali S.


  1. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Development, 2017. Tomaz RA, Harman JL, Karimlou D, Weavers L, Fritsch L, Bou-Kheir T, Bell E, Del Valle Torres I, Niakan KK, Fisher C, Joshi O, Stunnenberg HG, Curry E, Ait-Si-Ali S, Jørgensen HF and Azuara V. PMID : 28087629
  2. Tandem affinity Purification Approach coupled to Mass spectrometry to identify post-translational modifications of histones associated with chromatin binding proteins: the case of lysine methyltransferases. Methods in Molecular Biology, 2017. S Beyer, P Robin and S Ait-Si-Ali. PMID : 27832529


  1. Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation. Cell Discovery, 2016. Beyer S, Pontis J, L Fritsch, Schirwis E, Battisti V, Rudolf A, Le Grand F and S Ait-Si-Ali. PMID : 27790377
  2. Identification of MyoD interactome using Tandem Affinity Purification coupled to Mass Spectrometry. Journal of Visualized Experiments, 2016. E Boyarchuk, P Robin, L Fritsch, V Joliot and S Ait-Si-Ali. PMID : 27286495
  3. Unexpected distinct roles of the related histone H3 lysine 9 methyltarsferase G9a and G9a-Like Protein in myoblasts. J Mol Biol., 2016. V Battisti, J Pontis, Boyarchuk E, Fritsch L, P Robin, S Ait-Si-Ali and V Joliot. PMID : 27056598
  4. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. PLoS Genet., 2016. Lakisic G, Lebreton A, Pourpre R, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P, Bierne H. PMID : 26938916


  1. Sound of Silence: the properties and functions of repressive lysine methyltransferases. Nature Reviews Molecular Cell Biology, 2015. Mozzetta C, Boyarchuk E, Pontis J and Ait-Si-Ali S. PMID : 26204160
  2. The downregulation of BAP1 expression by BCR-ABL reduces the stability of BRCA1 in chronic myeloid leukemia. Experimental Hematology, 2015. F Dkhissi, D Aggoune, J Pontis, N Sorel, A LeCorf, F Guilhot, JC Chomel, S Ait-Si-Ali and AG Turhan. PMID : 26118501
  3. Functional Crosstalks Between Histone Lysine Methyltransferases. Antioxidants Redox Signaling , 2014. Mozzetta C, Pontis J and S Ait-Si-Ali S. PMID : 25365549
  4. A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. J Biol Chem, 2015. JM Simon, JS Parker, F Liu, S Rothbart, S Ait-Si-Ali, B Strahl, J Jin, I Davis, AL Mosley and SG Pattenden. PMID : 26338712
  5. An acetyltransferase assay for CREB-binding protein based on reverse phase-ultra-fast liquid chromatography of fluorescent histone H3 peptides.Analytical Biochemistry, 2015. R Duval, L Fritsch, LC Bui, F Guidez, C Mathieu, J Berthelet, JM Dupret, C Chomienne, S Ait-Si-Ali and Fernando Rodrigues-Lima. PMID : 26099937
  6. The preRC protein ORCA organizes Heterochromatin by Assembling Histone H3 1 Lysine 9 Methyltransferases on Chromatin. eLife, 2015. S Giri, V Aggarwal, J Pontis, Z Shen, A Chakraborty, A Khan, C Mizzen, KV Prasanth, S Ait-Si-Ali, T Ha and SG Prasanth. PMID : 25922909
  7. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature, 2015. J Marsolier, M Perichon, JD DeBarry, BO Villoutreix, J Chluba, T Lopez, C Garrido, XZ Zhou, KP Lu, L Fritsch, S Ait-Si-Ali, M Mhadhbi, S Medjkane, JB Weitzman. PMID : 25624101


  1. The SWI/SNF subunit/tumor suppressor BAF47/INI1 is essential in cell cycle arrest upon skeletal muscle terminal differentiation. PLoS One, 2014. Joliot V, Ait-Mohamed O, Battisti V, Pontis J, Philipot O, Robin P, Ito H, Ait-Si-Ali S. PMID : 25271443
  2. The Histone H3 lysine 9 Methyltransferases G9a and GLP Regulates Polycomb Repressive Complex 2-Mediated Gene Silencing. Molecular Cell, 2014. Highlighted in Nature Reviews Mol Cell Biol, Vol 15, Feb 2014. Mozzetta C, Pontis J, Fritsch L, Robin P, Portoso M, Proux C, Margueron R and Ait-Si-Ali S. PMID : 24389103
  3. PRMT5-mediated H4 arginine-3 symmetrical dimethylation marks chromatin at G+C-rich regions of the mouse genome. Nucleic Acids Res., 2014. M Girardot, R Hirasawa, S Kacem, L Fritsch, J Pontis, SK Kota, D Filipponi, E Fabbrizio, C Sardet, F Lohmann, S Kadam, S Ait-Si-Ali and R Feil. PMID : 24097435


  1. H19 lncRNA controls gene transcription of the Imprinted Gene Network by recruiting MBD1. Proc Natl Acad Sci U S A, 2013. P Monnier, J Pontis, C Martinet, I Stancheva, S Ait-Si-Ali and L Dandolo. PMID : 24297921
  2. Global decrease of histone H3K27 acetylation in ZEB1-induced epithelial to mesenchymal transition in lung cancer cells. Cancers (Basel), 2013. J Roche, P Nasarre, R Gemmill, A Baldys, C Korch, J Pontis, X Lu, A Baron, S Ait-Si-Ali and H Drabkin. PMID : 24216980


  1. SPOC1 Modulates DNA Repair by Regulating Key Determinants of Chromatin Compaction and DNA Damage Response. Nucleic Acids Res., 2012. Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, Fritsch L, Battisti V, Ait-Si-Ali S, Hoffbeck AS, Soutoglou E and Will H. PMID : 23034801
  2. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012 (updated in 2016). Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T etc… PMID : 22966490
  3. Argonaute proteins couple chromatin silencing to alternative splicing. Nature Structural and Molecular Biology, 2012. Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E and Harel-Bellan A. PMID : 22961379


  1. Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells. PLoS ONE, 2011. Ait-Mohamed O, Battisti V, Joliot V, Fritsch L, Pontis J, Redeuilh C, Lamouri A, Fahy C, Gholam M, Atmani D and Ait-Si-Ali S. PMID : 21935420
  2. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature, 2011. Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferre F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Merme CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA & Zon LI. PMID : 21430779
  3. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science, 2011. Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H. PMID : 21252314


  1. Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells. Epigenetics, 2010. Guasconi V, Pritchard LL, Fritsch L, Mesner LD, Francastel C, Harel-Bellan A and Ait-Si-Ali S. PMID : 20716953
  2. The Core Binding Factor CBF Negatively Regulates Skeletal Muscle Terminal Differentiation. PLoS ONE, 2010. Philipot O, Joliot V, Ait-Mohamed O, Pellentz C, Robin P, Fritsch L and Ait-Si-Ali S. PMID : 20195544
  3. A Subset of the H3 lysine 9 Methyltransferases Suv39h1, G9a, GLP and SETDB1 participate in a Multimeric Complex. Molecular Cell, 2010. Fritsch L, Robin P, Mathieu JR, Souidi M, Hinaux H, Rougeulle C, Harel-Bellan A, Ameyar-Zazoua M and Ait-Si-Ali S. PMID : 20129054

Slimane Ait-Si-Ali sur Pubmed