Claire Francastel sur PubMed
Florent Hubé sur PubMed
Guillaume Velasco sur PubMed




Francastel C, Magdinier F. DNA methylation in satellite repeats disorders. Essays Biochem. 2019; doi: 10.1042/EBC20190028. PMID: 31387943

Velasco G, Francastel C. Genetics meets dna methylation in rare diseases. Clin Genet. 2019; 95(2):210-220. PMID: 30456829



Toubiana S, Velasco G, Chityat A, Kaindl AM, Hershtig N, Tzur-Gilat A, Francastel C, Selig S. Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric Instability and Facial Anomalies (ICF) syndrome. Human Mol Genet. 2018; 27(20):3568-3581. PMID: 30010917


Velasco G, Grillo G, Touleimat N, Ferry L, Ivkovic I, Ribierre F, Deleuze JF, Chantalat S, Picard C, Francastel C. Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state. Human Mol Genet. 2018; 27(14):2409-2424. PMID: 29659838

Hubé F, Francastel C. Coding and non-coding RNAs, the frontier has never been so blurred. Front Genet. 2018; 9:140. PMID: 29720998

Tosolini M, Brochard V, Adenot P, Chebrout M, Grillo G, Navia V, Beaujean N, Francastel C, Bonnet-Garnier A, Jouneau A. Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells. Sci Rep. 2018; 8(1):5776. PMID: 29636490

Bogard B, Francastel C, Hubé F. A new method for the identification of thousands of circular RNAs . Non-coding RNA Investig. 2018; 2(5). Paper here

Achour C, Bogard B, Hubé F, Mani SA, Santulli GA, Taube JH. The Non-Coding RNA Journal Club: Highlights on Recent Papers-5. Non-coding RNA. 2017; 3(2). PMID: 29657292




Gatto S, Gagliardi M, Franzese M, Leppert S, Papa M, Cammisa M, Grillo G, Velasco G, Francastel C, Toubiana S, D’Esposito M, Angelini C, Matarazzo MR. ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. Nucleic Acids Res. 2017; 45(10):5739-5756. PMID: 28334849

Hédouin S, Grillo G, Ivkovic I, Velasco G, Francastel C. CENP-A chromatin disassembly in stressed and senescent murine cells. Sci Rep. 2017;7:42520. PMID: 28186195

Hubé F, Ulveling D, Sureau A, Forveille S, Francastel C. Short intron-derived ncRNAs. Nucleic Acids Res. 2017;45(8):4768-4781. PMID: 28053119

Sagie S, Toubiana S, Hartono S, Katzir H, Tzur-Gilat A, Havazelet S, Francastel C, Velasco G, Chedin F, Selig S. Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. Nat Commun. 2017;8:14015. PMID: 28117327



Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. Loss of the methyl-CpG binding protein ZBTB4 alters mitotic checkpoint, increases aneuploidy and promotes tumorigenesis . Cancer Res . 2016; pii: canres.1181. PMID: 27815388

Sterlin D, Velasco G, Moshous D, Touzot F, Mahlaoui N, Fischer A, Suarez F, Francastel C, Picard C. Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey . J Clin Immunol. 2016; 36(2):149-59. PMID: 26851945



Berindan-Neagoe I, Calin GA, Francastel C, Hubé F, Santulli G. The Non-Coding RNA Journal Club: Highlights on Recent Papers-3. Non-coding RNA. 2015; 1(3). Paper here

Francastel C, Hubé F, Mani SA, Santulli G Taube JH, Szweykowska-Kulinska Z. The Non-Coding RNA Journal Club: Highlights on Recent Papers-2. Non-coding RNA. 2015; 1(2), 167-169. Paper here


Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat Commun. 2015; 6:7870. PMID: 26216346

Hubé F, Francastel C. “Pocket-sized RNA-Seq”: a method to capture new mature microRNA produced from a genomic region of interest. Non-coding RNA. 2015; 1(2):127-138. PMID: 29861419

Ferracin M, Gautheret D, Hubé F, Mani SA, Ørom UA, Santulli G, Slotkin RK, Szweykowska-Kulinska Z, Taube JH, Vazquez F, Yang JH. The Non-Coding RNA Journal Club: Highlights on Recent Papers. Non-coding RNA. 2015; 1(1):87-93. Paper here

Hubé F, Francastel C. Mammalian Introns: When the Junk Generates Molecular Diversity. Int J of Mol Sci. 2015; 16(3):4429-4452. PMID: 25710723




Ulveling D, Dinger M, Francastel C, Hubé F. Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs. Front Genet. 2014; 5:316. PMID: 25250049

Walton E, Francastel C, Velasco G. Dnmt3b prefers germ line genes and centromeric regions: lessons from ICF and cancer and implications for diseases. Biology (Basel). 2014; 3(3):578-605. PMID: 25198254

Velasco G, Walton EL, Sterlin D, Hédouin S, Nitta H, Yuya I, Fouyssac F, Mégarbané A, Sasaki H, Picard C, Francastel C. Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology. Orphanet J Rare Dis. 2014; 9(1):56. PMID: 24742017



Nitta H, Unoki M, Ichiyanagi K, Kosho T, Shigemura T, Takahashi H, Velasco G, Francastel C, Picard C, Kubota T, Sasaki H. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. J Hum Genet. 2013; 58(7):455-60. PMID: 23739126



Walton EL, Francastel C, Velasco G. Maintenance of DNA methylation: Dnmt3b joins the dance. Epigenetics. 2011; 6(11):1373-7. PMID: 22048250

Ulveling D, Francastel C, Hubé F. When one is better than two: RNA with dual functions. Biochimie. 2011; 93(4):633-44. Review. PMID: 21111023

Ulveling D, Francastel C, Hubé F. Identification of potentially new bifunctional RNA based on genome-wide data-mining of alternative splicing events. Biochimie. 2011; 93(11):2024-7. PMID: 21729736

Perrot-Applanat M, Vacher S, Toullec A, Pelaez I, Velasco G, Cormier F, Saad Hel S, Lidereau R, Baud V, Bièche I. Similar NF-κB gene signatures in TNF-α treated human endothelial cells and breast tumor biopsies. PLoS One. 2011; 6(7):e21589. PMID: 21754991

Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J, Baud V. A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity. J Biol Chem. 2011; 286(37):32277-88. PMID: 21784860

Hubé F, Velasco G, Rollin J, Furling D, Francastel C. Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation. Nucleic Acids Res. 2011; 39(2):513-25. PMID: 20855289

Francastel C, Hubé F. Coding or non-coding: Need they be exclusive? Biochimie. 2011; 93(11):vi-vii. PMID: 21963143




Velasco G, Hubé F, Rollin J, Neuillet D, Philippe C, Bouzinba-Segard H, Galvani A, Viegas-Péquignot E, Francastel C. Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9281-6. PMID: 20439742

Guillemin C, Francastel C. [Heterochromatin compartments and gene silencing: human hematopoietic differentiation as a model study]. Biol Aujourdhui. 2010;204(3):221-33. Review. French. PMID: 20950566

Guasconi V, Pritchard LL, Fritsch L, Mesner LD, Francastel C, Harel-Bellan A, Ait-Si-Ali S. Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells. Epigenetics. 2010 Nov-Dec;5(8):704-9. PMID: 20716953



Guillemin C, Maleszewska M, Guais A, Maës J, Rouyez MC, Yacia A, Fichelson S, Goodhardt M, Francastel C. Chromatin modifications in hematopoietic multipotent and committed progenitors are independent of gene subnuclear positioning relative to repressive compartments. Stem Cells. 2009 Jan;27(1):108-15. PMID: 18974210

Ferri F, Bouzinba-Segard H, Velasco G, Hubé F, Francastel C. Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucleic Acids Res. 2009 Aug;37(15):5071-80. PMID: 19542185

Cooper C, Guo J, Yan Y, Chooniedass-Kothari S, Hube F, Hamedani MK, Murphy LC, Myal Y, Leygue E. Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides. Nucleic Acids Res. 2009 Jul;37(13):4518-31. PMID: 19483093



Skliris GP, Hubé F, Gheorghiu I, Mutawe MM, Penner C, Watson PH, Murphy LC, Leygue E, Myal Y. Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers. Histopathology. 2008 Feb;52(3):355-69. PMID: 18269587

Maës J, Maleszewska M, Guillemin C, Pflumio F, Six E, André-Schmutz I, Cavazzana-Calvo M, Charron D, Francastel C, Goodhardt M. Lymphoid-affiliated genes are associated with active histone modifications in human hematopoietic stem cells. Blood. 2008 Oct 1;112(7):2722-9. PMID: 18625888

Hervé MA, Buteau-Lozano H, Vassy R, Bieche I, Velasco G, Pla M, Perret G, Mourah S, Perrot-Applanat M. Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels. Am J Pathol. 2008 Jan;172(1):167-78. PMID: 18079435

Buteau-Lozano H, Velasco G, Cristofari M, Balaguer P, Perrot-Applanat M. Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism. J Endocrinol. 2008 Feb;196(2):399-412. PMID: 18252963



Velasco G, Grkovic S, Ansieau S. New insights into BS69 functions. J Biol Chem. 2006 Jun 16;281(24):16546-50. PMID: 16565076

Motohashi H, Katsuoka F, Miyoshi C, Uchimura Y, Saitoh H, Francastel C, Engel JD, Yamamoto M. MafG sumoylation is required for active transcriptional repression. Mol Cell Biol. 2006 Jun;26(12):4652-63. PMID: 16738329

Hube F, Myal Y, Leygue E. The promoter competition assay (PCA): a new approach to identify motifs involved in the transcriptional activity of reporter genes. Front Biosci. 2006 May 1;11:1577-84. PMID: 16368538

Hube F, Myal Y, Leygue E, Rollin J, Gruel Y. Expression of two breast-specific molecules in the lung. J Mol Diagn. 2006 Jul;8(3):390-1; author reply 391-3. PMID: 16831819

Hube F, Guo J, Chooniedass-Kothari S, Cooper C, Hamedani MK, Dibrov AA, Blanchard AA, Wang X, Deng G, Myal Y, Leygue E. Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. DNA Cell Biol. 2006 Jul;25(7):418-28. PMID: 16848684

Hubé F, Chooniedass-Kothari S, Hamedani MK, Miksicek RJ, Leygue E, Myal Y. Identification of an octamer-binding site controlling the activity of the small breast epithelial mucin gene promoter. Front Biosci. 2006 Sep 1;11:2483-95. PMID: 16720387

Chooniedass-Kothari S, Hamedani MK, Troup S, Hubé F, Leygue E. The steroid receptor RNA activator protein is expressed in breast tumor tissues. Int J Cancer. 2006 Feb 15;118(4):1054-9. PMID: 16152589

Bouzinba-Segard H, Guais A, Francastel C. Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8709-14. PMID: 16731634



Rollin J, Iochmann S, Bléchet C, Hubé F, Régina S, Guyétant S, Lemarié E, Reverdiau P, Gruel Y. Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer. Br J Cancer. 2005 Feb 28;92(4):775-83. PMID: 15685245

Hubé F, Reverdiau P, Iochmann S, Gruel Y. Improved PCR method for amplification of GC-rich DNA sequences. Mol Biotechnol. 2005 Sep;31(1):81-4. Review. PMID: 16118416



Hubé F, Mutawe M, Leygue E, Myal Y. Human small breast epithelial mucin: the promise of a new breast tumor biomarker. DNA Cell Biol. 2004 Dec;23(12):842-9. PMID: 15684711

Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. PMID: 15147866

Brand M, Ranish JA, Kummer NT, Hamilton J, Igarashi K, Francastel C, Chi TH, Crabtree GR, Aebersold R, Groudine M. Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics. Nat Struct Mol Biol. 2004 Jan;11(1):73-80. PMID: 14718926



Hubé F, Reverdiau P, Iochmann S, Trassard S, Thibault G, Gruel Y. Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas. Biol Reprod. 2003 May;68(5):1888-94. PMID: 12606321

Hubé F, Reverdiau P, Iochmann S, Rollin J, Cherpi-Antar C, Gruel Y. Transcriptional silencing of the TFPI-2 gene by promoter hypermethylation in choriocarcinoma cells. Biol Chem. 2003 Jul;384(7):1029-34. PMID: 12956419

Hubé F, Reverdiau P, Iochmann S, Gruel Y. Computer model of the interaction of human TFPI-2 Kunitz-type serine protease inhibitor with human plasmin. Thromb Res. 2003;111(3):197-8. PMID: 14678821

Hubé F, Reverdiau P, Iochmann S, Cherpi-Antar C, Gruel Y. Characterization and functional analysis of TFPI-2 gene promoter in a human choriocarcinoma cell line. Thromb Res. 2003 Feb 15;109(4):207-15. PMID: 12757776

Brossay A, Hubé F, Moreau T, Bardos P, Watier H. Porcine CD58: cDNA cloning and molecular dissection of the porcine CD58-human CD2 interface. Biochem Biophys Res Commun. 2003 Oct 3;309(4):992-8. PMID: 13679072



Iochmann S, Reverdiau-Moalic P, Hubé F, Bardos P, Gruel Y. Demonstration of inducible TFPI-2 mRNA synthesis in BeWo and JEG-3 trophoblast cells using a competitive RT-PCR. Thromb Res. 2002 Feb 1;105(3):217-23. PMID: 11927127



Francastel C, Magis W, Groudine M. Nuclear relocation of a transactivator subunit precedes target gene activation. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12120-5. PMID: 11593025



Schübeler D, Francastel C, Cimbora DM, Reik A, Martin DI, Groudine M. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev. 2000 Apr 15;14(8):940-50. PMID: 10783166

Francastel C, Schübeler D, Martin DI, Groudine M. Nuclear compartmentalization and gene activity. Nat Rev Mol Cell Biol. 2000 Nov;1(2):137-43. Review. PMID: 11253366

Cimbora DM, Schübeler D, Reik A, Hamilton J, Francastel C, Epner EM, Groudine M. Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region. Mol Cell Biol. 2000 Aug;20(15):5581-91. PMID: 10891496

Schübeler D, Francastel C, Cimbora DM, Reik A, Martin DI, Groudine M. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev. 2000 Apr 15;14(8):940-50. PMID: 10783166

Francastel C, Schübeler D, Martin DI, Groudine M. Nuclear compartmentalization and gene activity. Nat Rev Mol Cell Biol. 2000 Nov;1(2):137-43. Review. PMID: 11253366

Cimbora DM, Schübeler D, Reik A, Hamilton J, Francastel C, Epner EM, Groudine M. Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region. Mol Cell Biol. 2000 Aug;20(15):5581-91. PMID: 10891496



Francastel C, Walters MC, Groudine M, Martin DI. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin. Cell. 1999 Oct 29;99(3):259-69. PMID: 10555142



Le Naour F, Francastel C, Prenant M, Lantz O, Boucheix C, Rubinstein E. Upregulation of CD9 expression during TPA treatment of K562 cells. Leukemia. 1997 Aug;11(8):1290-7. PMID: 9264383

Francastel C, Poindessous-Jazat V, Augery-Bourget Y, Robert-Lézénès J. NF-E2p18/mafK is required in DMSO-induced differentiation of Friend erythroleukemia cells by enhancing NF-E2 activity. Leukemia. 1997 Feb;11(2):273-80. PMID: 9009092

Francastel C, Augery-Bourget Y, Prenant M, Walters M, Martin DI, Robert-Lézénès J. c-Jun inhibits NF-E2 transcriptional activity in association with p18/maf in Friend erythroleukemia cells. Oncogene. 1997 Feb 20;14(7):873-7. PMID: 9047395



Le Naour F, Prenant M, Francastel C, Rubinstein E, Uzan G, Boucheix C. Transcriptional regulation of the human CD9 gene: characterization of the 5’ flanking region. Oncogene. 1996 Aug 1;13(3):481-6. PMID: 8760289



Francastel C, Groisman R, Pfarr CM, Robert-Lézénès J. Antisense c-jun overcomes a differentiation block in a murine erythroleukemia cell line. Oncogene. 1994 Jul;9(7):1957-64. PMID: 8208542



Francastel C, Mazouzi Z, Robert-Lézénès J. Co-induction of c-fos and junB during the latent period preceding commitment of Friend erythroleukemia cells to differentiation. Leukemia. 1992 Sep;6(9):935-9. PMID: 1518304