Immediate perturbation of DNA methylation upon acute prenatal alcohol exposure in the mouse developing brain cortex. A Duchateau, N Auperin, F Miozzo, A Le Mouel, O Kirsh, M Mohamed, S Ott, D Saberan-Djoneidi, V Mezger.

Epigenome priming dictates transcription response and white matter fate upon perinatal inflammation. AL Schang, J van Steenwinckel, J Lipecki, C Rich-Griffin, K Woolley-Allen, N Dyer, T Le Charpentier, P Schäfer, B Fleiss, S Ott, D SabéRan-Djoneidi, V Mezger, P Gressens.

CBP/EP300 acetylates and stabilizes the stress-responsive Heat Shock Factor 2, a process compromised in Rubinstein-Taybi syndrome. A de Thonel, JK Ahlskog, R Abane, G Pires, V Dubreuil, J Berthelet, A L. Aalto, S Naceri, M Cordonnier, C Benasolo, M Sanial, A Duchateau, A Vihervaara, MC Puustinen, F Miozzo, M Henry, D Bouvier, JP Concordet, P Fergelot, E Lebigot, A Verloes, P Gressens, D Lacombe, J Gobbo, C Garrido, SD Westerheide, M Petitjean, O Taboureau, F Rodrigues-Lima, M Lancaster, S Passemard, D Sabéran-Djoneidi, L Sistonen, V Mezger.


Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2. Pesonen L, Svartsjö S, Bäck V, de Thonel A, Mezger V, Sabéran-Djoneidi D, Roos-Mattjus P. Cell Stress Chaperones. 2021 Sep;26(5):819-833. doi: 10.1007/s12192-021-01222-4. Epub 2021 Jul 30. PMID: 34331200

Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. Drissi I, Deschamps C, Alary R, Robert A, Dubreuil V, Le Mouël A, Mohammed M, Sabéran-Djoneidi D, Mezger V, Naassila M, Pierrefiche O. Addict Biol. 2021 Jul 27:e12939. PMID: 32720424


The « HSF connection »: Pleiotropic regulation and activities of Heat Shock Factors shape pathophysiological brain development. Duchateau A, de Thonel A, El Fatimy R, Dubreuil V, Mezger V. Neurosci Lett. 2020 Apr 23;725:134895. PMID: 32147500

Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion. Joutsen J, Da Silva AJ, Luoto JC, Budzynski MA, Nylund AS, de Thonel A, Concordet JP, Mezger V, Sabéran-Djoneidi D, Henriksson E, Sistonen L. Cell Rep. 2020 Jan 14;30(2):583-597.e6. PMID: 31940498


Neuroinflammation in preterm babies and autism spectrum disorders. Bokobza C, Van Steenwinckel J, Mani S, Mezger V, Fleiss B, Gressens P. Pediatr Res. 2019 Jan;85(2):155-165. PMID: 30446768


HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A. Nat Commun. 2018 Apr 12;9(1):1431. doi: 10.1038/s41467-018-03627-9. PMID: 29650953

Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms. Miozzo F, Arnould H, de Thonel A, Schang AL, Sabéran-Djoneidi D, Baudry A, Schneider B, Mezger V. Cell Stress Chaperones. 2018 Jan;23(1):115-126. PMID: 28712054

The impact of epigenomic next-generation sequencing approaches on our understanding of neuropsychiatric disorders. Schang AL, Sabéran-Djoneidi D, Mezger V. Clin Genet. 2018 Mar;93(3):467-480.. PMID: 28696507


Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Nat Commun. 2017 May 2;8:15157. PMID: 28462912

Methylomic changes during conversion to psychosis. Kebir O, Chaumette B, Rivollier F, Miozzo F, Lemieux Perreault LP, Barhdadi A, Provost S, Plaze M, Bourgin J; ICAAR team, Gaillard R, Mezger V, Dubé MP, Krebs MO. Mol Psychiatry. 2017 Apr;22(4):512-518. PMID: 27113994


HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes. Miozzo F, Sabéran-Djoneidi D, Mezger V. J Mol Biol. 2015 Dec 4;427(24):3793-816. Review. PMID: 26482101


Heat shock in the springtime. Morano KA, Sistonen L, Mezger V. Cell Stress Chaperones. 2014 Nov;19(6):753-61. PMID: 25199949

Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome. El Fatimy R, Miozzo F, Le Mouël A, Abane R, Schwendimann L, Sabéran-Djoneidi D, de Thonel A, Massaoudi I, Paslaru L, Hashimoto-Torii K, Christians E, Rakic P, Gressens P, Mezger V. EMBO Mol Med. 2014 Jul 15;6(8):1043-61. PMID: 25027850

A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation. Papanayotou C, Benhaddou A, Camus A, Perea-Gomez A, Jouneau A, Mezger V, Langa F, Ott S, Sabéran-Djoneidi D, Collignon J. PLoS Biol. 2014 Jun 24;12(6):e1001890. PMID: 24960041

Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Neuron. 2014 May 7;82(3):560-72.  PMID: 24726381

Early environmental factors, alteration of epigenetic marks and metabolic disease susceptibility. Portha B, Fournier A, Kioon MD, Mezger V, Movassat J. Biochimie. 2014 Feb;97:1-15. Review. PMID: 24139903


Transcriptional regulation of small HSP-HSF1 and beyond. de Thonel A, Le Mouël A, Mezger V. Int J Biochem Cell Biol. 2012 Oct;44(10):1593-612. Review. PMID: 22750029


Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A. Mol Biol Cell. 2011 Oct;22(19):3571-83. PMID: 21813737

Implication of heat shock factors in tumorigenesis: therapeutical potential. De Thonel A, Mezger V, Garrido C. Cancers (Basel). 2011 Mar 7;3(1):1158-81. PMID: 24212658


Roles of heat shock factors in gametogenesis and development. Abane R, Mezger V. FEBS J. 2010 Oct;277(20):4150-72. Review. PMID: 20945531