Annuaire

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Guillaume VéLASCO
Assistant Professor / Univ. Paris 7
Equipe : Methylation de l’ADN et ARNs non-codants en physiopathologie
Pièce n°: 411

Guillaume is Maître de conférences (Lecturer) at the University Paris Diderot since 2011. He's teaching molecular biology and epigenetics in Licence and Master. In the lab, he works on the role of DNA methylation in physiopathological contexts. He is focusing on the ICF syndrome, a rare monogenetic disease associated with defects in DNA methylation landscapes, to identify and better understand molecular mechanisms that control the establishment and maintenance of DNA methylation in mammals.
Guillaume obtained his PhD in Molecular and Cellular Biology from the Ecole Normale Supérieure de Lyon (France) in 2006. He joined Claire Francastel's lab in 2008 to do his post-doc, first in the Hematology Department of the Cochin Institute, then at the Epigenetic and Cell Fate Unit (Paris).

Corresponding links

Université Paris-Diderot
Institut Cochin
Université Paris-Descartes
ENS Lyon
Centre Léon-Bérard

Selected Publications

Velasco G, Grillo G, Touleimat N, Ferry L, Ivkovic I, Ribierre F, Deleuze JF, Chantalat S, Picard C, Francastel C. Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state. Human Mol Genet. 2018; doi: 10.1093/hmg/ddy130. PMID: 29659838

Gatto S, Gagliardi M, Franzese M, Leppert S, Papa M, Cammisa M, Grillo G, Velasco G, Francastel C, Toubiana S, D'Esposito M, Angelini C, Matarazzo MR. ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. Nucleic Acids Res. 2017 Mar 9; 45(10):5739-5756. PMID: 28334849

Sagie S, Toubiana S, Hartono S, Katzir H, Tzur-Gilat A, Havazelet S, Francastel C, Velasco G, Chedin F, Selig S. Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. Nat Commun. 2017 Jan 24;8:14015. PMID: 28117327

Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat Commun. 2015 Jul 28;6:7870. PMID: 26216346

Sterlin D, Velasco G, Moshous D, Touzot F, Mahlaoui N, Fischer A, Suarez F, Francastel C, Picard C. Genetic, Cellular and Clinical Features of ICF Syndrome: a French National Survey . J Clin Immunol. 2016 Feb;36(2):149-59. PMID: 26851945

Guillaume Velasco sur PubMed